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Chicken Pot Pie Casserole with Cheddar Biscuit Topping

4.0 (36 ratings)
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By Ella
Prep Time 20 min
Cook Time 35 min
Calories 485 kcal
Difficulty Easy

Ingredients

Servings

Directions / Instructions

Why You'll Love This Chicken Pot Pie Casserole

If you love classic chicken pot pie but want something even easier to prepare, this casserole is the perfect solution. A rich, creamy chicken filling loaded with tender vegetables is topped with buttery cheddar biscuits instead of traditional pie crust, creating an irresistible combination of flavors and textures.

The fluffy cheese biscuits bake until golden while soaking up just enough of the creamy filling underneath. It's a hearty one-pan meal that's ideal for weeknight dinners, meal prep, or feeding a hungry family.

Ingredients

For the Filling

  • 3 cups cooked chicken, shredded or diced
  • 2 tablespoons unsalted butter
  • 1 small onion, diced
  • 2 cloves garlic, minced
  • 2 cups frozen mixed vegetables (peas, carrots, corn, green beans)
  • 1/4 cup all-purpose flour
  • 2 cups chicken broth
  • 1 cup whole milk
  • 1 teaspoon dried thyme
  • 1/2 teaspoon dried parsley
  • 1/2 teaspoon black pepper
  • 1 teaspoon salt

For the Cheddar Biscuit Topping

  • 2 cups all-purpose flour
  • 1 tablespoon baking powder
  • 1/2 teaspoon salt
  • 1/2 teaspoon garlic powder
  • 1/4 cup cold unsalted butter, cubed
  • 1 cup shredded sharp cheddar cheese
  • 3/4 cup buttermilk
  • 2 tablespoons melted butter
  • 1 tablespoon chopped fresh parsley

Instructions

1. Prepare the Filling

Preheat the oven to 375°F (190°C). Melt the butter in a large skillet over medium heat. Sauté the onion until softened, then add the garlic and cook for 30 seconds. Stir in the mixed vegetables.

2. Make the Cream Sauce

Sprinkle the flour over the vegetables and cook for 1 minute. Gradually whisk in the chicken broth and milk until smooth. Add the thyme, parsley, salt, and pepper, then simmer until the sauce thickens.

3. Add the Chicken

Fold the cooked chicken into the creamy sauce and transfer the mixture to a lightly greased 9x13-inch baking dish.

4. Prepare the Biscuit Dough

In a large bowl, whisk together the flour, baking powder, salt, and garlic powder. Cut in the cold butter until the mixture resembles coarse crumbs. Stir in the shredded cheddar cheese, then add the buttermilk and mix just until combined.

5. Top the Casserole

Drop large spoonfuls of biscuit dough evenly over the chicken filling, leaving small gaps so steam can escape during baking.

6. Bake

Bake for 25 to 30 minutes, or until the biscuit topping is golden brown and cooked through. Brush the biscuits with melted butter and sprinkle with fresh parsley immediately after baking.

7. Serve

Allow the casserole to rest for 5 to 10 minutes before serving warm.

Expert Tips

Use rotisserie chicken to save time and freshly shredded cheddar for the best flavor and melt. Don't overmix the biscuit dough to keep the topping light and fluffy. If the biscuits brown too quickly, loosely cover the casserole with foil during the final minutes of baking.

Storage

Store leftovers in an airtight container in the refrigerator for up to 4 days. Reheat in a 350°F (175°C) oven until warmed through, or microwave individual portions. Freeze the baked casserole for up to 2 months and thaw overnight before reheating.

Serving Suggestions

Serve with a crisp green salad, roasted asparagus, steamed broccoli, green beans, cranberry sauce, or fresh dinner rolls. This hearty casserole is a complete meal but also pairs wonderfully with light vegetable sides.

Recipe Variations

Substitute turkey for chicken after the holidays, add sautéed mushrooms, diced potatoes, celery, or spinach, or use pepper jack cheese for a spicy twist. Fresh herbs like rosemary, sage, or dill also add delicious flavor to the filling and biscuits.

Frequently Asked Questions

Yes. Prepare the filling a day in advance and refrigerate it. Add the freshly made biscuit topping just before baking.
Absolutely. Rotisserie chicken is one of the easiest and most flavorful options for this casserole.
Yes. Bake, cool completely, wrap tightly, and freeze for up to 2 months. Thaw overnight in the refrigerator before reheating.
Yes. Refrigerated biscuit dough is a convenient substitute, although homemade cheddar biscuits provide richer flavor and texture.
Frozen mixed vegetables are convenient, but fresh carrots, peas, corn, celery, mushrooms, green beans, and potatoes are all excellent additions.
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